The second goal of the platform under development is to also allow immediate point of contact induction of TH by infusing a quantity of crystalloid solution chilled to 4oC. In an average size adult, hypothermia induction can typically be achieved by a bolus of 30cc/kg (maximum of 2 liters) of chilled normal saline given at a rate of 100cc/minute.
Significant improvement in neurological recovery has been demonstrated in non-traumatic cardiac arrest survivors if started within six hours of resuscitation. Besides an American Heart Association recommendation for TH, a substantial and growing number of Hospitals and civilian EMS systems have adopted TH as a standard of care and start the inclusion and induction process in the field.
A major challenge to EMS regarding TH is maintaining a supply of chilled saline to have immediately available in the field in every vehicle that could treat a cardiac arrest survivor. This requires installation and maintenance of coolers which require a constant power supply whether the vehicle is in use or not.
Our TH technology under development is an easy to use disposable which connects to our heating/cooling portable power control unit. When attached in cooling mode and normal saline is infused through the system, a rapid heat sink is achieved with proprietary technology chilling ambient temperature saline on contact as it flows into the patient. This eliminates the need for vehicles to be equipped with storage coolers and makes fluid cooling and induction of TH possible in the most Austere conditions with ambient temperature stock saline.